The Gurkar lab is interested in defining the molecular mechanisms that drive aging in response to endogenous DNA damage, which accumulates in all of us over time. The majority of individuals over the age of 65 years suffer from at least two chronic degenerative diseases- neurodegeneration, cardiovascular disease, diabetes, cancer etc. These chronic diseases of the elderly consume an increasingly large fraction of our health care costs and rob individuals of their independence and quality of life. Developing therapies to target the primary risk factor for all of these diseases, aging itself, is a promising yet challenging solution. The first step is to define the molecular mechanisms that drive aging. We believe that this will reveal novel therapeutic targets that can be further harnessed to extend healthy life.
Zhang L., Zhao J., Gurkar AU., Niedernhofer LJ., and Robbins PD. (2018) Methods to quantify the NF-κB pathway during senescence. Cell Senescence - Methods in Molecular Biology. Submitted.
Niedernhofer L.J., Gurkar A.U., Wang Y., Vijg J., Hoeijmakers J. and Robbins P.D. (2018) Nuclear instability and aging. (Annual Review of Biochemistry)
Gurkar A.U.* and Finkel T. (*corresponding author) (2017) Synergistic treatment of TS. Oncotarget News
The worm club attends Pirates baseball game, May 2018.
Check out one of our favorite artist. Greg Dunn designs.
National Geographic Channel’s series directed by Ron Howard highlighted aging research as a breakthrough in Nov 2015.
We are looking for fun, skilled and highly motivated individuals excited to work with a scientific team focused on understanding the base of age-related disease such as neurodegeneration, cancer and cardiovascular disease.
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Lab Manager/ Research Specialist