The Gurkar lab is interested in defining the molecular mechanisms that drive aging in response to endogenous DNA damage, which accumulates in all of us over time. The majority of individuals over the age of 65 years suffer from at least two chronic degenerative diseases- neurodegeneration, cardiovascular disease, diabetes, cancer etc. These chronic diseases of the elderly consume an increasingly large fraction of our health care costs and rob individuals of their independence and quality of life. Developing therapies to target the primary risk factor for all of these diseases, aging itself, is a promising yet challenging solution. The first step is to define the molecular mechanisms that drive aging. We believe that this will reveal novel therapeutic targets that can be further harnessed to extend healthy life.
Niedernhofer L.J., Gurkar A.U., Wang Y., Vijg J., Hoeijmakers J. and Robbins P.D. (2017) Nuclear instability and aging. (invited review for Annual Review of Biochemistry submitted)
Gurkar A.U.* and Finkel T. (*corresponding author) (2017) Synergistic treatment of TS. Oncotarget News
Zhao J, Fuhrmann-Stroissnigg H, Gurkar AU, Flores RR, Dorronsoro A, Stolz DB, St Croix CM, Niedernhofer LJ, Robbins PD. (2017) Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Curr Protoc Cytom.
Gurkar, A.U*. Gill M.S. and Niedernhofer L.J. (*corresponding author) (2016) The role of DNA damage in longevity-lessons from the nematode. Book: C. elegans and its contribution to longevity and ageing research M. S. Gill and A. Olsen ed (Springer) *corresponding author
Radiolab can be heard as a podcast produced by WNYC. Jad Abumrad and Robert Krulwich are gifted storytellers and bring science to life in every episode! We have too many favorites to list here- don't forget to listen to Update: CRISPR
Breakthroughs “Age of Aging” : National Geographic Channel’s series directed by Ron Howard highlighted aging research as a breakthrough in Nov 2015.
We are looking for fun, skilled and highly motivated individuals excited to work with a scientific team focused on understanding the base of age-related disease such as neurodegeneration, cancer and cardiovascular disease.
Send c.v. with name, email, and phone numbers of references to firstname.lastname@example.org
Lab Manager/ Research Specialist