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Publication & Funding


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Publications

Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU., McGowan SJ, Kosicki K, Bednarek M, Zarakowska E, Gackowski D, Oliński R, Speina E, Niedernhofer LJ, Tudek B. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radical Biol Med.

Gurkar AU., Robinson A.R., Cui Y., Li X., Allani S.K., Webster A., Muravia M., Fallahi M., Weissbach H., Robbins P.D., Wang Y., Kelley E.E., St. Croix C.M., Niedernhofer L.J. and Gill M.S. Dysregulation of DAF-16/FOXO3-mediated stress responses acceleratesoxidative DNA damage induced aging. Redox Biol. In Press.

Zhang L., Zhao J., Gurkar AU., Niedernhofer LJ., and Robbins PD. Methods to quantify the NF-κB pathway during senescence. Cell Senescence - Methods in Molecular Biology. Submitted.

Robinson A.R., Yousefzadeh M.J., Rozgaja T.A., Wang J., Li X. , Tilstra J.S., Feldman C. H., Gregg S. Q., Johnson C.H., Skoda E.M., Frantz M-C., Bell-Temin H., Pope-Varsalona H., Gurkar AU., Nasto L.A., Robinson R.A., Fuhrmann-Stroissnigg H., Czerwinska J., McGowan S.J., Cantu-Medellin N., Harris J.B., Maniar S., Ross M.A., Trussoni C.E., LaRusso N.F., Cifuentes-Pagano E., Pagano P.J., Tudek B., Vo N., Rigatti L.H., Opresko P.L., Stolz D.B., Watkins S.C., Burd C.E., St. Croix C.M., Siuzdak G., Yates N.A., Robbins P.D., Wang Y., Wipf P., Kelley E.E.† and Niedernhofer L.J.† Spontaneous DNA damage to the nuclear genome promotes senescence and aging. Redox Biol

Niedernhofer L.J., Gurkar AU., Wang Y., Vijg J., Hoeijmakers J. and Robbins P.D. Nuclear instability and aging. (Annual Review of Biochemistry)

Gurkar AU.* and Finkel T. (*corresponding author) Synergistic treatment of TS. Oncotarget News

Zhao J, Fuhrmann-Stroissnigg H, Gurkar AU., Flores RR, Dorronsoro A, Stolz DB, St Croix CM, Niedernhofer LJ, Robbins PD. Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Curr Protoc Cytom.

Gurkar, AU.* Gill M.S. and Niedernhofer L.J. (*corresponding author) The role of DNA damage in longevity-lessons from the nematode. Book: C. elegans and its contribution to longevity and ageing research M. S. Gill and A. Olsen ed (Springer) *corresponding author

Gurkar AU. and Niedernhofer LJ. Comparison of mice with accelerated aging caused by distinct mechanisms. Exp Gerontol.

Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW. Small-Molecule Reactivation of Mutant p53 to Wild-Type- like p53 through the p53-Hsp40 Regulatory Axis. Chem Biol.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell.

Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW. Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun.

Gurkar AU, Chu K, Lee SW. DNA repair and Cancer. Madhusudan S, Wilson III DM, editors. Boca Raton, FL: CRC Press; Chapter 12, p53 in DNA Damage, Repair and Cancer Therapeutics; p.372-426. 679p.

Barkley LR, Palle K, Durando M, Day TA, Gurkar A, Kakusho N, Li J, Masai H, Vaziri C. c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks. Mol Biol Cell.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature.

Song IY, Palle K, Gurkar A, Tateishi S, Kupfer GM, Vaziri C. Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway. J Biol Chem.

Qiu X, Gurkar AU, Lory S. Interstrain transfer of the large pathogenicity island (PAPI-1) of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A.